Publications Applied Research


Publications Applied Research

• Dimpfel W, Vonderheid-Guth B, Wedekind W (2001) Das quantitative EEG als elektrischer "Fingerprint" von Phytopharmaka bei Ratte und Mensch. Zeitschrift für Phytotherapie 22: 22-27.

• Vonderheid-Guth B, Todorova A, Wedekind W, Dimpfel W (2000) Evidence for neuronal dysfunction in migraine: concurrence between specific qEEG findings and clinical drug response - a retrospective analysis. Eur J Med Res 5: 473-483.

• Dimpfel W, Schober F (2000) An EEG-based algorithm for definition of depth of anesthesia. DAK Congress Bochum-Poster.

• Dimpfel W, Schober F (2000) An EEG-derived spectral frequency index (SFX) provides reliable quantitation of depth of sedation and sleep. 11th International Conference on Pharmaceutical Medicine in Berlin.

• Vonderheid-Guth B, Todorova A, Brattström A, Dimpfel W (2000) Pharmacodynamic Effects of Valerian and Hops Extract Combination (ZE 91019) on the Quantitative-Topographical EEG in Healthy Volunteers Eur J Med Res 5: 139-144.

• Dimpfel W, Todorova A, Vonderheid-Guth B (1999) Pharmacodynamic properties of St. John´s Wort. A Single blind neurophysiological study in healthy subjects comparing two commercial preparations. Eur J Med Res 4: 303-312.

• Renz D, Dimpfel W, Schober F, Karliczek GF (1999) Bedeutung des Spektralen Frequenzindex (SFx) zur Qauantifizierung der Schlaftiefe während der Narkoseeinleitung. Acta Anaesthesologica Helvetia 2: 9-11.

• Dimpfel W, Schombert L (1998) Central action of hyperici herba cum flore extractum siccum in freely moving rats. Eur J Med Res 2: 491-496.

• Dimpfel W, Schober F, Mannel M (1998) Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Pharmacopsychiatry 31: 30-35.

• Todorova A, Schellenberg R, Hofmann H.C, Dimpfel W (1998) Effect of the Ecternal Nasal Divator Breathe Right® on snoring. Eur J Med Res 3: 367-379.

• Schellenberg, Sauer S, Dimpfel W (1998) Pharmacodynamic Effects of two Different Hypericum Extracts in Healthy Volunteers Measured by Quantitative EEG. Pharmacopsychiat 31: 44-53.

• Dimpfel W, Hofmann H.C, Schober F, Todorova A (1998) Validation of an EEG-Derived Spectral Frequency Index (SFx) for continuous monitoring of sleep depth in humans. Eur J Med Res 3: 453-460.

• Schellenberg R, Todorova A, Wedekind W, Schober F, Dimpfel W (1997). Pathophysiology and psychopharmacology of dementia - A new study design. 2. Cyclandelate Treatment - a Placebo-Controlled Double-Blind Clincal Trial. Neuro-psychobiology 35: 132 – 142.

• Todorova A, Hofmann H.C, Dimpfel W (1997) A New Frequency Based Automatic Sleep Analysis - Description of the Healthy Sleep. Eur J Med Res 2: 185–197.

• Sauer S, Schellenberg R, Hofmann H.C, Dimpfel W (1997) Functional Imaging of Headache - First Steps in an Objective Classification of Migraine. Eur J Med Res 2: 367-376.

• Dimpfel W, Hofmann HC, Prohaska A, Schober F, Schellenberg R. (1996) Source Density Analysis of Funcitonal Topographical EEG: Monitoring of Cognitive Drug Action. Eur J Med Res 1: 283 - 290.

• Dimpfel W, Dalhoff A, von Keutz E (1996) In vitro modulation of hippocampal pyramidal cell response by quinolones: effects of HA 966 and gamma-hydroxybutyric acid. Antimicrob Agents Chemother 40: 2573-2576.

• Dimpfel W (1996) Effect of thioctic acid on pyramidal cell responses in the rat hippocampus in vitro. Eur J Med Res 1: 523-527.

• Schober F., Schellenberg R., Dimpfel W (1995) Reflection of mental exercise in the dynamic quantitative topographical EEG. Neuropsychobiology 31: 98-112.

• Schellenberg R., Todorova A., Dimpfel W., Schober F (1995) Pathophysiology and psychopharmacology of dementia - a new study design. 1. Diagnosis - comprising subjective and ovjective criteria. Neuropsychobiology 32: 81 – 97.

• Dimpfel W (1995) Effects of memantine on synaptic transmission in the hippocampus in vitro. Arzneimittelforschung 45: 1-5.

• Schober F, Schellenberg R, Dimpfel W (1995) Reflection of mental exercise in the dynamic quantitative topographical EEG. Neuropsychobiology 31: 98-112.

• Dimpfel W, Hofmann R (1995) Pharmacodynamic effects of St. John's Wort on rat intracerebral field potentials. Eur J Med Res 1: 1157-67.

• Dimpfel W, Chatterjee SS, Nöldner M, Ticku MK (1995) Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system. Epilepsia 36: 983-9.

• Weis J, Dimpfel W, Schröder JM (1995) Nerve conduction changes and fine structural alterations of extra- and intrafusal muscle and nerve fibers in streptozotocin diabetic rats. Muscle Nerve 18: 175-84.

• Dimpfel W, Hofmann H-C (1995) Mehrdimensionale Dokumentation des Schlafes auf der Grundlage der Frequenzanalyse. In: Mayer G. (Hrsg.) Jahrbuch Schlafmedizin in Deutschland 1994, MMV Medizin Verlag, München.

• Schellenberg R, Todorova A, Hofmann H-C, Dimpfel W, Schober F (1995) Differentiation of demented patients and healthy subjects by means of quantitative-topological EEG - a classifcation approach. Alzheimer's Research 1: 23 - 28

• Reiser H-P, Dimpfel W, Schober F (1995) The Influence of Electromagnetic Fields on Human Brain Activity. Eur J Med Res 1: 27-32.

• Zickmann B, Boldt J, Mangold J, Wulf K, Dapper F, Hempelmann G (1995) Quantifizierung und Topographie der zerebralen Leistungsänderung durch moderate Hypothermie während extrakorporaler Zirkulation. Z. Herz-, Thorax-, Gefäßchir. 9: 205-212.

• Dimpfel W, Schober F, Wedekind W, Kleinbloesem C, Coors C (1994) Nachweis pharmakokinetischer-pharmakodynamischer Beziehungen mittels Pharmako-EEG bei gesunden Probanden nach Verabreichung von Cyclandelat. Arzneim Forsch./Drug Res 44: 999-1004.

• Todorova A, Dimpfel W (1994) Multiunit activity from the A9 and A10 areas in rats following chronic treatment with different neuroleptic drugs. Eur Neuropsychopharmacol 4:491-501.

• Dimpfel W, Hofmann H.C (1994) Central Nervous System Monitoring; Reduction of Information Content of Quantitative Electroencephalograms for Continuous On-Line Display During Anesthesia. In: Schulte am Esch J., Kochs E., (Hrsg) Central Nervous System Monitoring in Anesthesia and Intensive Care, Springer Verlag, Berlin.

• Dimpfel W (1994) Pharmakologische Aspekte der Analgosedierung. In: Das traumatisch-hirnorganische Psychosyndrom Bauer B. L., Springer Verlag, Berlin.

• Schellenberg R, Milch W, Schwarz A, Schober, Dimpfel W (1994) Quantitative EEG and BPRS-data following Haldol-Deconoate® administration in schizophrenics. J Clin Psychopharmacol 9: 17-24.


• Schober F, Schellenberg R, Dimpfel, W (1994) Neue Wege zur Beurteilung der mentalen Leistungsfähigkeit mittels simultaner topograph ischer Elektroenzephalometrie und Psychometrie in der Pharmakologie. Arzneim.-Forsch/Drug Res 44: 1285 – 1295.

• Schober F, Schellenberg R, Dimpfel, W (1994) A new method for assessment of mental performance during simultaneous, quantitative, topographical electroencephalometry and psychometry in pharmacology. Proof of the effect of a combination of biogenic amines, vitamins, minerals and trace elements. Arzneimittelforschung 44:1285-1295.

• Dimpfel W, Dalhoff A, Hofmann W, Schlüter G (1994) Electrically evoked potentials in the rat hippocampus slice in the presence of aminophylline alone and in combination with quinolones. Eur Neuropsychopharmacol 4:151-156.

• Pietzko A, Dimpfel W, Schwantes U, Topfmeier P (1994) Influences of trospium chloride and oxybutynin on quantitative topographical EEG in healthy volunteers. Eur J Clin Pharmacol 47: 337-343.

• Dimpfel W, Schober F, Spüler M (1993) The Influence of Caffeine on Human EEG under Resting Conditions and during Mental Load. The Clinical Investigator 71: 197-207.

• Schellenberg R, Schober F, Dimpfel, W (1993) Nürnberger Altersinventar performed simultaneously with continuous Computer Aided Topographical Electroencephalometry (CATEEM®) in mildly demented patients. In: M. Eiselt, U. Zwiener, H. Witte (Hrsg) Quantitative and topological EEG and MEG analysis. Universitätsverlag Druckhaus-Meyer GmbH, Jena.

• Dimpfel W, Spüler M, Wessel K (1992) Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats. Psychopharmacology Berlin 107: 195-202.

• Dimpfel W, Wedekind W, Spüler M (1992) Field potential analysis in the freely moving rat during the action of cyclandelate or flunarizine. Pharmacol Res 25: 287-297.

• Dimpfel W., Schober F., Spüler M (1992) Influence of Caffeine on Human EEG under Resting Conditions and while Performing Mental Arithmetic. Klin Pharmakol 1: 71-72.

• Schober F, Dimpfel W (1992) Relation between psychometric tests and quantitative topographic EEG in pharmacology. Int J Clin Phamacol Ther Toxikol 30: 428-430.

• Dimpfel W, Spüler M, Dalhoff A, Hofmann W, Schlüter G (1991) Hippocampal activity in the presence of quinolones and fenbufen in vitro. Antimicrob Agents Chemother 35: 1142-1146.

• Dimpfel W, Spüler M, Netter P, Wedekind W (1991) Wirkung von Cyclandelat auf das ZNS - Eine doppelblind, placebo-kontrollierte Studie an gesunden Probanden. Klin Wochenschrift 69: 313-319.

• Dimpfel W, Spüler M, Bonke D (1990) Influence of repeated vitamin B administration on the frequency pattern analysed from rat brain electrical activity (Tele-Stereo-EEG). Klin Wochenschr 68: 136-141.

• Dimpfel W, Spüler M (1990) Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission. Psychopharmacology (Berlin) 101: 317-323.

• Dimpfel W, Spüler M, Pierau FK, Ulrich H (1990) Thioctic acid induces dose-dependent sprouting of neurites in cultured rat neuroblastoma cells. Dev Pharmacol Ther 14: 193-199.

• Dimpfel W, Spüler M, Menge HG (1989) Effects of the antiparkinson drug budipine on EEG activity in unrestrained rats. Arzneimittelforschung 39: 560-563.

• Dimpfel W, Spüler M, Nichols DE (1989). Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacology (Berl) 98: 297-303.

• Dimpfel W, Spüler M, Nickel B (1989). Dose- and time-dependent action of morphine, tramadol and flupirtine as studied by radioelectroencephalography in the freely behaving rat. Neuropsychobiology 20: 164-168.

• Dimpfel W, Spüler M (1988) Neurophysiologische Studien zum Aktivitätsprofil von Memantin. In: "Memantine-Workshop: Expertengespräche (1988). Budapest, W. Zuckschwerdt Verlag, München, Bern, Wien, San Francisco.

• Dimpfel W, Spüler M, Borbe HO (1988) Monitoring of the effects of antidepressant drugs in the freely moving rat by radioelectroencephalography (Tele-stereo-EEG). Neuropsychobiology 19: 116-120.

• Spüler M, Dimpfel W, Tüllner HU (1988) Ganglioside therapy in experimental diabetic neuropathy. Arzneimittelforschung 38: 881-884.

• Dimpfel W, Spüler M, Koch R, Schatton W (1987) Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats. Neuropsychobiology 18: 212-218.

• Spüler M, Dimpfel W, Tüllner HU (1987) Effect of gangliosides on nerve conduction velocity during diabetic neuropathy in the rat. Arch Int Pharmacodyn Ther 287: 211-223.

• Dimpfel W, Spüler M, Nickel B (1986) Radioelectroencephalography (Tele-Stereo-EEG) in the rat as a pharmacological model to differentiate the central action of flupirtine from that of opiates, diazepam and phenobarbital. Neuropsychobiology 16: 163-168.

• Dimpfel W, Spüler M, Nickel B, Tibes U (1986) 'Fingerprints' of central stimulatory drug effects by means of quantitative radioelectroencephalography in the rat (Tele-stereo-EEG). Neuropsychobiology 15: 101-108.

• Dimpfel W, Decker H (1985) Classification of sulpiride, clozapine and haloperidol by toposelective recording from different brain structures in the immobilized rat (stereo-EEG). Neuropsychobiology 14: 157-164.

• Dimpfel W (1985) Drug-induced field potential changes in dopaminergic target areas after electrical stimulation of the rat mesencephalon. Neuropsychobiology 14: 42-52.